Many are not aware that arthritis problems may come in different types. There are 100 various types of arthritis and some of these can impact an individual in spite of age and gender. Rheumatoid arthritis is among the most popular forms of arthritis affliction which is incapacitating for the affected individual. In case you are unacquainted with the indications of the disease, it will be difficult for you to determine whether you are afflicted with it. That is why you have to find out what causes arthritis, its symptoms along with the available treatments. Regarding rheumatoid arthritis, listed below are some of the most basic information that you need to know.
Rheumatoid arthritis is a prominent characteristic found in the blood which can be considered as an antibody that binds certain kinds of antigens. These antigens normally include various probable dangers to the body’s defense mechanisms. For instance, foreign tissues, bacteria, foreign blood cells and toxins are all regarded as antigens. The antibodies and the immune system guard the body from these trespassers to ensure that the body is free from the health issues. Nonetheless, if more antigens are found than antibodies, this can endanger the immune system and result to a number of conditions. In rheumatism, the lining within the joints contain activated cells which induces chronic inflammation and emotional stress.
Experts believe an individual’s hypothalamus has a huge role in the progression of rheumatoid arthritis. The hypothalamus gland may stimulate the stress response called CRH or corticotrophin-releasing hormone. The CRH, however, will generate adrenocoricotropic hormones that may further initiate the release of glucocorticoids from the adrenal cortex. These glucocorticoids function in unison and it regulates the metabolism of protein and fats and manages carbohydrates in the body. In their normal functions, these also have anti-inflammatory benefits on the body. Nevertheless, in rheumatoid arthritis, the over-stimulation of these hormones due to stress or infections can lead to excessive amount of cortisol. So instead of becoming an anti-inflammatory, it becomes pro-inflammatory due to the response of receptors in the abnormal amount of cortisol which is considered to be what causes rheumatoid arthritis.
The Role of Cortisol and HPA Axis
The activation of the HPA or the hypothalamic-pituitary-adrenal axis caused by acute stress is accumulative in nature which leads to unfavorable physiological effects, consequently bringing on defective glucose metabolic process and leads to diabetes and excessive weight, long-term hippocampal damage and depression. These modifications in rheumatoid arthritis might result in a metabolic disease that is accompanied by a jeopardized immune system along with excessive amount of cortisol. This will then cause a sedentary lifestyle, increased insulin resistance or rapid disease progression, glucose intolerance and heart diseases.
Take note that rheumatoid arthritis can result in significant alterations in the body that may impact an individual’s life. This is why it should be identified in the course of its initial phases to ensure proper cure can be administered to cure its signs and prevent it from aggravating. You should do not forget that all arthritis problems could be incapacitating so you need to become acquainted with the illness. For example, should you be suffering with hip arthritis, it is possible to speak with your physician concerning the characteristics of the ailment as well as the treatment options ideal for you.
What causes arthritis? The condition can be caused by various factors and it can be frustrating if you are to do a study on it. However, for distinct types of arthritis in fingers, you can just ask a physician on what causes arthritis in fingers, its indications and also the treatment solutions readily available for the problem.
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